TY  - JOUR
T1  - Randomized Double-Blind Control Trial to Study the Efficacy of Topical Herbal
Product-<i>Curcuma xanthorrhiza</i> (Temulawak) in the
Treatment of Hyperpigmented Scar
AU - Mat Saad, Arman Zaharil AU - Halim, Ahmad Sukari AU - Ahmad Zaidi, Ahmad Ibrahim AU - Wan Sulaiman, Wan Azman AU - Ujang, Zanariah AU - Nordin, Nurul Izza AU - Abd Rashid, Ahmad Hazri AU - Ahmad Zaidi, Nur Adnin 
JO  - Journal of Engineering and Applied Sciences
VL  - 13
IS  - 17
SP  - 7432
EP  - 7439
PY  - 2018
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2018.7432.7439
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2018.7432.7439
KW  - Curcuma
KW  -anti-inflammatory agent
KW  -antioxidant
KW  -hyperpigmentation
KW  -rating
KW  -role
AB  - <i>Curcuma xanthorrhiza</i> (Temulawak) has been tested to have a certain properties that can be used
in treatment of hyperpigmentation which is tyrosinase inhibitor, anti-oxidant, broad spectrum anti-bacterial,
antiseptic and anti-inflammatory. In this study, we want to explore the potential of Temulawak as an alternative
solution for skin hyperpigmentation treatment. A randomized double blind placebo control trial involving 58
patients with hyperpigmented scar were randomly divided into two groups. Patients were required to apply the
topical cream evenly to their scar twice a day; One in the morning and the other during bed time. The patients
were screened after at least 6 weeks after wound has healed. The evaluations of scar were done by medical
practitioner, patient himself and also by independent photographic assessor. Patients, investigator and
independent photographic assessor were blinded to the topical application. The mean age of patients was 39
years old (between 24-53 years old), 32 were female and 6 participants lost to follow up and excluded from
study. Analyzed hyperpigmented scars were distributed at head and neck area (53.8%), limbs (40.4%) and trunk
(5.8%). Hyperpigmentation, pain, itchiness and overall scar rating showed higher score decrement (better scar
outcome) in the intervention group compared to control group. There was no adverse skin reaction recorded
in both intervention and control groups. The result of our study were not statistically significant. This is due
to the limitation of the Vancouver Scar Scale and small sample size. However, we still believe that Temulawak
has the potential role as an alternative treatment for scar hyperpigmentation.
ER  -