TY  - JOUR
T1  - Hepatoprotective and Haematopoietic Modulatory Efficacy of Leaf Extract of
<i>Colocasia esculenta</i> in Albino Wistar Rats
AU - Eluke, Blessing Chekwube AU - Dayo, Olalere Fatai AU - Ukaejiofo, Ernest Okem AU - Olayinka, Olatubosun Luqman AU - Johnpaul, Chukwu Ikechukwu AU - Tajudeen, Ogunwale Ayobami Kolawole AU - Chinwe, Ikegwuonu Ifeoma AU - Adetona, LawaL Sikiru AU - Abdulrasak, Nafiu AU - Olugbenga, Afolabi Onaolapo AU - Abdurraheem, Abioye Adesola Idowu 
JO  - International Journal of Tropical Medicine
VL  - 12
IS  - 3
SP  - 35
EP  - 41
PY  - 2017
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2017.35.41
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2017.35.41
KW  - Haematopoietic
KW  -hepatoprotective
KW  -Colocasia esculenta
KW  -Wistar albino rats
KW  -availability
KW  -properties
AB  - The study was done to investigate the haematopoietic and hepatoprotective modulatory effects of
the leaf extract of <i>Colocasia esculenta</i> in Carbon tetrachloride (CCl<sub>4</sub> ) induced hepatotoxic Wistar rats. About 
30 albino Wistar rats were divided into six groups of six per group for the study. Group 1 served as the control
group and received no treatment while group 2 was the negative control and was treated with 0.5 mg/kg CCl<sub>4</sub>
only. Group 3 served as the positive control and was treated with CCl<sub>4</sub> and 100 mg/kg silymarin. Groups 4-6 were 
all induced with CCl<sub>4</sub> and then administered with varying doses of the extract (100, 200 and 400 mg/kg, 4
respectively). Blood samples were collected from all rats after 14 days under ether anesthesia following
international guidelines on the use and handling of animals and were subjected to laboratory analysis according
to standard techniques. The result obtained revealed that the Aqueous leaf Extract of <i>Colocasia esculenta</i>
(AECE) at varying doses further significantly decreased all estimated markers of liver function (Aspartate
Transaminase (AST) Alanine Transaminase (ALT) and Alanine Phosphatase (ALP) after the administration of
CCl<sub>4</sub> . The extracts equally showed increased in platelet (thrombocytosis), however, total White Cell count 
(WBC), Haemoglobin (Hb), Red Cell count (RBC), Packed Cell Volume (PCV) and red cell indices were
statistically significantly reduced (p&lt;0.05). Tissue morphology was restored by the AECE at varying doses. The
findings revealed that leaf extract of <i>Colocasia esculenta</i> possesses potent hepatoprotective properties
enhanced thrombopoiesis and is a potential agent to correct hepatotoxicity premised on its efficacy,
affordability, safety and availability following standardization/clinical trials.
ER  -