TY  - JOUR
T1  - Hypoadiponectinemia Associated in Obesity and Type 2 Diabetes and
Hyperadiponectinemia Closed with Type I Diabetes
AU - Haghnazari, Lida AU - Nomani, Hamid AU - Nowroozi, Hamed AU - Hesami, Osman AU - Rahimi, Mehrali AU - Foroughinia, Sahar 
JO  - International Journal of Tropical Medicine
VL  - 11
IS  - 5
SP  - 165
EP  - 169
PY  - 2016
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2016.165.169
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2016.165.169
KW  - Type 1 and 2 diabetes
KW  -adiponectin
KW  -Body Mass Index (BMI)
KW  -lipid profiles
KW  -biochemical marker
AB  - Adiponectin decreases in Type 2 diabetes mellitus, insulin resistance and obesity. However,
increases in several chronic statuses such as Type I diabetes associated with nephropathy or cardiovascular
diseases. In this study, we investigated whether serum level of adiponectin may be considered as a useful
biochemical marker for differentiating T1DM and T2DM and correlation with lipid profiles, waist circumstance
and body mass index in Kermanshah population, West of Iran. This cross-sectional study was conducted on
100 diabetic patients Type 2 and 89 diabetic Type I and 99 and 66 non diabetic as control group matched for
age and sex with T2DM and T1DM, respectively. Levels of adiponectin, HbA1c, lipid profiles were measured
by ELISA, glycated hemoglobin and enzyme assay, respectively. Our finding showed, levels of serum
adiponectin significantly increased in T1DM patients and decreased in T2DM patients. In addition, serum
adiponectin concentration in T1DM patients was significantly higher of T2DM . Serum adiponectin level was
significantly positive correlation with HbA1c in T1DM and with HDL-C in T2DM. Lipid profiles except
of HDL-C were significantly higher in T2DM patients compared with T1DM patients. There was a
significantly negative correlation between serum levels of adiponectin and obesity in T1DM and T2DM.
Hypoadiponectinemia associated with obesity and T2DM patients while closed with T1DM and decrease BMI
and serum adiponectin concentration which may be considered as a useful biochemical marker for differentiating
T1DM and T2DM.
ER  -