TY  - JOUR
T1  - Mechanisms of Antiulcerogenic Effect of Garlic (<I>Allium sativum</I>) in 
  Albino Rats
AU - Gabriel, Adedeji Temitope AU - Tope, Salaudeen Aminat AU - Sunday, Oluwole Francis 
JO  - International Journal of Tropical Medicine
VL  - 8
IS  - 5
SP  - 119
EP  - 123
PY  - 2013
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2013.119.123
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2013.119.123
KW  - Allium sativum
KW  -antioxidant
KW  -anti-ulcer activity
KW  -gastric mucus cell
KW  -groups
AB  - The aim of the present study was to investigate the possible 
  effects of garlic juice as well as feed supplemented with <I>Allium sativum</I>, 
  on gastric ulceration, antioxidant activity and gastric mucus cell count in 
  wistar rats. The animals used were divided into six groups and treated for 30 
  days. A low dose (250 mg kg<SUP>-1</SUP> body weight) and high dose (500 mg 
  kg<SUP>-1</SUP>) of garlic juice was orally administered to two of the experimental 
  groups while two other groups were fed with 5 and 10% <I>Allium sativum</I>/standard 
  feed mix. The control group was fed on the standard rats&#146; 
  feed and water only while a positive control group was given Misoprostol (10 
  mg kg<SUP>-1</SUP>) orally as a standard drug. The result showed that pre-treatment 
  with garlic was significantly effective in reducing gastric ulceration incidence 
  in animals (p&lt;0.05) as mean ulcer score decreased significantly in all groups 
  treated with garlic. Superoxide Dismutase (SOD) and Catalase (CAT) increased 
  significantly, especially in animals in the high dose group. Malonyldialdehyde 
  (MDA) concentration however decreased mainly in both the group given a high 
  dose of garlic juice (500 mg kg<SUP>-1</SUP>) and the group fed with 10% supplemented 
  <I>Allium sativum</I> feed while gastric mucus cell count was also significantly 
  increased in most treatment groups. These results suggest that garlic decreases 
  ulcerogenesis in experimental animals. This can be attributed to its effects 
  of increasing antioxidant activity and gastric mucous cell count.
ER  -