TY  - JOUR
T1  - Evaluation of Anticoagulant Property of Aqueous and Ethanolic Extracts of <I>Morinda citrifolia</I>
AU - Noor, Sabariah Md AU - Karim, Mohd Arif Abdul AU - Seman, Zainina AU - Tohit, Eusni Rahayu Mohd AU - Idris, Faridah 
JO  - International Journal of Tropical Medicine
VL  - 8
IS  - 1
SP  - 1
EP  - 5
PY  - 2013
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2013.1.5
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2013.1.5
KW  - Morinda citrifolia
KW  -plant based polysaccharide
KW  -coagulation assays
KW  -anticoagulant activity
KW  -MCAE
AB  - Anticoagulant is an agent used to treat patients with cardiovascular diseases by preventing new clots formation. It works by inhibiting blood from clotting, therefore preventing progression of thrombosis. Heparin, the animal based polysaccharides is a widely used anticoagulant has many adverse effects. This study aimed to evaluate the effects of <I>Morinda citrifolia</I> Aqueous Extract (MCAE) and Ethanolic Extract (MCEE) on plasma coagulation <I>in vitro</I>. Platelet Poor Plasma (PPP) from fifty healthy volunteers was incubated with different concentrations of extracts (10, 20, 30, 40 and 50 mg mL<SUP>-1</SUP>) and subjected for clotting assays of Prothrombin Time (PT) and Activated Partial Thrombosplastin Time (APTT). The samples that been incubated by MCAE and MCEE showed prolongation of PT and APTT. These findings indicated that <I>Morinda citrifolia</I> extracts has anticoagulant effect <I>in vitro</I> and also suggest that it may become a potential plant based anticoagulant which is should be effective and safe for clinical need in dealing with patient with cardiovascular disorders.
ER  -