TY  - JOUR
T1  - Effects of a Type V Phosphodiesterase Inhibitor (Tadalafil) on Indomethacin-Induced Gastric Ulceration in Rats
AU - Kolawole, I. Ajiboye AU - Francis, S. Oluwole 
JO  - International Journal of Tropical Medicine
VL  - 7
IS  - 3
SP  - 111
EP  - 116
PY  - 2012
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2012.111.116
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2012.111.116
KW  - Tadalafil
KW  -gastric ulcer
KW  -PDE V inhibitors
KW  -ulcer
KW  -ulcer nitric oxide
KW  -cGMP
AB  - Gastric ulcer is one of the most prevalent gastrointestinal 
  disorders and still remains a major on-going health concern. Phosphodiesterase 
  V inhibitors (PDE V) are drugs currently used in the treatment of patients with 
  erectile dysfunction and pulmonary hypertension. They act by increasing blood 
  flow to tissues in response to increased cGMP levels. They are also Nitric Oxide 
  (NO) donors. NO is a potent vasodilator which increases blood flow in tissues 
  where present thus preventing tissue damage. This study therefore examined the 
  effects Tadalafil (TAD) on Indomethacin-induced gastric ulceration in rats. 
  Three studies were directed at examining the effects of Tadalafil on gastric 
  ulceration, ulcer dimensions and histological profile in indomethacin-induced 
  rats. Male Wistar Albino rats weighing between 180-220 g were used. Each experimental 
  group containing 6 rats were divided based on the following pre-treatments: 
  Group I (Control)-saline (8 mL kg<sup>-1</sup>), Group II-IV were pre-treated 
  with graded doses of Tadalafil (2, 5 and 10 mg kg<sup>-1</sup> body weight, 
  respectively), Group V (Reference)-Cimetidine 100 mg kg<sup>-1</sup>. Ulcer 
  was induced by administration of indomethacin (40 mg kg<sup>-1</sup> p.o) 30 
  min following pre-treatments. Results showed that Tadalafil significantly reduced 
  Indomethacin-induced gastric ulcers when compared with the control group (p&lt;0.05) 
  at high doses. The ulcer area, depth and width were significantly different 
  between the control group and the Tadalafil 10 mg kg<sup>-1</sup> BW group. 
  Tadalafil had ulcer-reducing effects similar to that of the reference drug, 
  cimetidine. Similar pattern of dose-dependent attenuation of ulcer severity 
  was observed in the histological study. This study provides evidence that Tadalafil 
  possesses significant anti-gastric ulcer effects as it dose-dependently reduced 
  gastric ulcers induced by Indomethacin in rats.
ER  -