TY  - JOUR
T1  - Evaluation of Antimicrobial Activities of Extracts of Five Plants Used in Traditional Medicine in Nigeria
AU - , Ekundayo, E.O. AU - , L.I. Ezeogu 
JO  - International Journal of Tropical Medicine
VL  - 1
IS  - 2
SP  - 93
EP  - 96
PY  - 2006
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2006.93.96
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2006.93.96
KW  - Medicinal plants
KW  -antimicrobial activities
KW  -methanol extracts
AB  - Ten extracts from five Nigerian medicinal plants were screened for antimicrobial activity using disc
agar diffusion and micro dilution broth assays. Methanol and Dichloromethane extracts of each of the plants
were tested against five collection culture microorganisms consisting of two Gram positive <I>(Staphylococcus
aureus </I>ATCC 12600, <I>Bacillus subtilis </I>ATCC 6051) and two Gram negative <I>(Escherichia coli </I>ATCC 11775 and
<I>Pseudomonas aeruginosa </I>ATCC 10145) bacteria and the pathogenic yeast, <I>Candida albican</I>s(ATCC 18804).
All the extracts exhibited moderate to high level of broad spectrum antimicrobial activities against these
microorganisms. The antimicrobial activity was measured by the diameter of zone of inhibition and Minimum
Inhibitory Concentration (MIC). The diameters of zones of inhibition range from 7mm-30mm at 2000µg mL of
crude extract per disc. The MIC values were between 31.5µg mL-500µg mL or greater. The activities of some of
the crude extracts were comparable to the reference antibiotics at standard concentrations used per disc. The
potential of these Nigerian medicinal plants for development of cheap, culturally acceptable standardized herbal
medicines and as sources of novel molecules for broad spectrum antimicrobial agents is discussed.
ER  -