TY  - JOUR
T1  - The Inhibition of Betel Leaf Infusion <i>(Piper betle Linn)</i>
Against the Growth of <i>Candida albicans</i>
AU - Ria, Ngena AU - Siregar, Ice Ratnalela AU - , Salbiah AU - Setyawati, Dewi 
JO  - Research Journal of Pharmacology
VL  - 13
IS  - 3
SP  - 32
EP  - 34
PY  - 2019
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2019.32.34
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2019.32.34
KW  - Candida albicans
KW  -inhibitory
KW  -infuse of betel
KW  -herbal medicine
KW  -antiseptic
KW  -bacteria and fungi
AB  - One of plants commonly used by the community for herbal medicine is betel (<em>Piper betle Linn</em>). The
reason is that betel contains antiseptic substances that can kill germs. Betel nutritious overcome infection
caused by bacteria and fungi. One of fungi that infects humans is <em>Candida albicans</em>. This study was
conducted to find out the effectiveness of some concentration of inhibitory power of green leaf infusion to the
growth of <em>Candida albicans</em>. The experiment was conducted between May and August 2017 at laboratory
Centre of Poltekkes Kemenkes in Medan, Indonesia. Different concentrations were made with 7 types of boiling
water of green betel leaves using sizes of 0.6, 1.0, 1.4, 1.8, 2.2, 2.6 and 3 g. Furthermore, various concentrations
of green betel infuse were installed by using the diffusion disc method. One way anova was employed for
analysing normal distributed data and post-hoc test was also used to determine the difference of
inhibitory power for each concentration. Results show that infusion of betel leaf from various concentrations
proved in inhibiting the growth of <em>Candida albicans</em> with p = 0.00 (<0.05). The mean of inhibitory zone
values of each concentration were 12.10 (0.6), 14.10 (1.0), 15.80 (1.4), 17.40 (1.8), 20.40 (2.2), 22.50 (2.6) and 24.50
mm (3.0 g). While, the drag zone on positive control with ketoconazole were at 36.20 mm. This study also explain
that the more number of leaves used in the manufacture of infuse, the more width of the inhibitory zone to
<em>Candida albicans</em> growth. The results on post-hoc test show that there is no different inhibitory effect of each
green betel infusion concentration to the growth of <em>Candida albicans</em> with p = 0.00 (<0.05).
ER  -