TY - JOUR T1 - A Comparative Study of 0.25% Bupivacaine with Clonidine, Fentanyl, Midazolam, as Adjuvants for Brachial Plexus Block AU - Pradeep, M. AU - , Sreekala JO - Research Journal of Medical Sciences VL - 19 IS - 3 SP - 99 EP - 103 PY - 2025 DA - 2001/08/19 SN - 1815-9346 DO - makrjms.2025.3.99.103 UR - https://makhillpublications.co/view-article.php?doi=makrjms.2025.3.99.103 KW - Bupivacine KW - brachial plexus block AB -

several local anaesthetic drugs used for brachial plexus block, Bupivacaine is used most frequently as it has a long duration of action varying from 3‐ 8 hours. To prolong the duration of analgesia various drugs have been studied as adjuvants to local anaesthetic solution and techniques like the continuous catheter placement in the plexus have evolved. The aim of the present study is to evaluate the effects of addition of 1 mcg/kg of preservative free clonidine to the maximum of 75 mcg, 1 mcg/kg of preservative free fentanyl to the maximum of 50mcg and 50mcg/kg of preservative free midazolam to 30ml of 0.25%. 60 adult patients of both sexes in the age group of 20‐60 years belonging to ASA I/II category and their weight ranging between 40‐70 kgs posted for various types of upper limb surgeries at the Department of Orthopedics and Department of surgery at sree Mookambika institute medical sciences the study group. This study was designed as a prospective randomised comparative study. Supra clavicular technique was chosen for this study because it provides a rapid onset, dense and predictable anaesthesia with a high success rate. Clonidine an α2‐adrenergic agoinst has been extensively used an adjunct to general anaesthesia and regional anaesthesia. When added to 1% mepivacaine6 with 1:2,00,000 epinephrine 150mcg of clonidine prolongs the duration of both anaesthesia and analgesia after axillary brachial plexus blockade. In conclusion, clonidine 1mcg/kg to a maximum of 75mcg added to 0.25% Bupivacaine solution for supra clavicular brachial plexus block, quickens the onset of sensory and motor blockade, prolongs the duration of sensory blockade, improves the quality of postoperative analgesia when compared to fentanyl and midazolam group.

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