TY - JOUR T1 - Study of Role of Hormonal Status in the Management of Breast Carcinoma in a Hospital Based Study AU - Gopinath, Vinu AU - Sreelakshmi, J.B. JO - Research Journal of Medical Sciences VL - 17 IS - 7 SP - 981 EP - 985 PY - 2023 DA - 2001/08/19 SN - 1815-9346 DO - 10.59218\makrjms.2023.981.985 UR - https://makhillpublications.co/view-article.php?doi=10.59218\makrjms.2023.981.985 KW - Breast cancer KW - hormone receptor KW - ER positive KW - breast carcinoma AB -

To assess the role of hormonal status in the management of breast carcinoma patients. Sixty-eight breast cancer females were selected. The confirmed cases of breast carcinoma patients were proceeded with surgical management followed by adjuvant/neoadjuvant therapy/palliative therapy according to their ER/PR/HER/2 NEU status. After surgery biopsy sent for HPE and IHC for their ER/PR/HER2/neu status chemotherapy/radiotherapy was given. The most common molecular subtype of breast cancer found in our study was Luminal A accounting for 48.53% of the cases. This was followed by Basal type (26.47%) and Luminal B type (20.59%). The most common histology found on final HPE analysis was invasive carcinoma breast no specific type accounting for 72.06% of the patients. This was followed by infiltrating ductal carcinoma accounting for 23.53% of the patients. Majority of ER positive cases 22 out of 48 were in the age group of 50-59 years. Majority of PR positive cases 14 out of 34 were in the age group of 50-59 years. 50% of the patients belonged to luminal A category, 26.47% of the patients belonged to triple negative category, 20.58% of the patients belonged to luminal B category and 2.94% of the patients belonged to Her2neu rich category. Patients with elderly age group are more likely to have hormone receptor status positivity. Hormone receptor-positive tumors are more likely to be larger than those with hormone receptor-negative tumors. Hormone receptor-positive tumors are also more likely to have more lymph node metastasis clinically as well as histologically, whereas according to the literature states the reverse is true.

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