TY  - JOUR
T1  - Prophylactic Role of Vitamin E and Olive Oil on Some Physiological and Histological Alterations of Male Rabbits Liver Exposed to Cadmium
AU - Al. Agha, Salam Z. AU - Al. Yazji, Nehad R. AU - N. Sunalla, Najah 
JO  - Research Journal of Biological Sciences
VL  - 9
IS  - 2
SP  - 73
EP  - 84
PY  - 2014
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2014.73.84
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2014.73.84
KW  - Cadmium chloride
KW  -vitamin E
KW  -olive oil
KW  -liver
KW  -biochemical parameters
KW  -histology
AB  - This experiment pertains to the protective role of vitamin E and olive oil 
  against Cadmium (Cd)-induced toxicity on glucose, total cholesterol, triglycerides 
  and bilirubin, enzyme activities of alanine Amino Transaminase (ALT), Aspartate 
  Amino Transaminase (AST) and Alkaline Phosphatase (ALP) and on liver tissue 
  of New Zealand rabbits. New Zealand white male rabbits weighing 800-1000 g were 
  used in the present study. Rabbits divided into 4 groups. The 1st group is the 
  control group and received only deionized water orally for 8 weeks. The 2nd 
  group received a dose of (2 mg kg<SUP>-1</SUP> b.wt.) of CdCl<SUB>2</SUB> daily. 
  The 3rd group received a dose of (150 mg kg<SUP>-1</SUP> b.wt.) vitamin E prior 
  CdCl<SUB>2</SUB> administration daily. The 4th group received a dose of (1 mL 
  kg<SUP>-1</SUP> b.wt.) olive oil prior CdCl<SUB>2</SUB> administration daily. 
  Animals of both control and experimental subgroups were decapitated weekly. 
  Administration of CdCl<SUB>2</SUB> showed highly significant increases in serum 
  glucose, cholesterol, bilirubin, triglyceride concentration and ALT, AST and 
  ALP activities all over the experimental periods (p&le;0.01). However, pretreatment 
  with vitamin E and olive oil decreased serum glucose and total cholesterol all 
  over the experimental periods to become near normal. The histopathological alterations 
  were manifested in the liver of the CdCl<SUB>2</SUB> treated rabbits. Hepatocellular 
  damage as congestion in the central and portal veins with dilation of these 
  veins and congestion in sinusoids degenerative hepatocytes showed with cytomegaly 
  clearly observed at 4th week. Also, diffuse Kupffer cells between the degenerative 
  hepatocytes showed obviously in the 1st and 4th weeks. The histopathological 
  studies in the liver of rats also showed that vitamin E and olive oil markedly 
  reduced the toxicity of cadmium and preserved the normal histological architecture 
  of the tissue. The present study suggested that vitamin E and olive oil may 
  be beneficial in ameliorating the cadmium-induced oxidative damage in the liver 
  of rabbits.
ER  -