TY  - JOUR
T1  - The Effect of Hydro-alcoholic Extract of Grape Seed (<I>Vitis vinifera</I>) on Sugar and Lipids in Serum of Diabetic Rats
AU - Shakeri, Farzaneh AU - Rostamian, Vahid AU - Estakhr, Jasem 
JO  - Research Journal of Biological Sciences
VL  - 6
IS  - 10
SP  - 547
EP  - 549
PY  - 2011
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2011.547.549
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2011.547.549
KW  - Grape seed
KW  -blood sugar
KW  -lipid profile
KW  -insulin
KW  -diabetic rats
KW  -Iran
AB  - Now-a-days, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. This study aimed at assessing the effect of grape seed extract on the blood glucose and lipid profile in diabetic rats. A total of 30 male adult rats were randomly selected and divided into 3 groups as; non-diabetic control, diabetic control and diabetic rats treated with hydroalcoholic extract of grape seed. In diabetic groups, alloxan monohydrate (120 mg kg<SUP>-1</SUP>) was injected intraperitoneally to develop diabetes. Then the test group received intraperitoneal injection of hydro-alcoholic extract of grape seed (100 mg kg<SUP>-1</SUP>). At last, glucose, cholesterol, triglyceride, HDL, VLDL, LDL and insulin contents of the rats' serum sample were determined. Diabetic rats treated with extract showed a significant decrease in blood glucose level (p&lt;0.05). Furthermore, compared diabetic group, in the extract-treated rats, there was a significant decrease in serum contents of Total Cholesterol (TC), LDL, VLDL and TG but a significant increase in insulin level and HDL (p&lt;0.05). These results show that the hydroalcoholic extract of grape seed may be effective in the treatment of diabetes. This effect can be due to the presence of flavonoides and their antioxidant features.
ER  -