TY  - JOUR
T1  - Effect of Carprofen on Pentylenetetrazole-Induced Seizure Threshold in Mice
AU - Mirhadi, Khayatnouri 
JO  - Research Journal of Biological Sciences
VL  - 6
IS  - 10
SP  - 496
EP  - 506
PY  - 2011
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2011.496.506
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2011.496.506
KW  - Carprofen
KW  -seizure
KW  -PTZ
KW  -threshold
KW  -mice
KW  -Iran
AB  - The Cyclooxygenases (COXs), the key enzymes that convert arachidonic acid to Prostaglandins (PGs) have been implicated in physiological and pathophysiological functions in the CNS. NSAIDs (Non-stesoidal Anti-Inflammatory Drugs), COX inhibitors are used largely to treat febrile condition, pain state and for prevention of and therapeutics of many diseases. However, the role of PGs and NSAIDs in the seizure activity has been disputed. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of Carprofen on PTZ-induced seizure threshold in mice. Mice were divided into 9 groups randomly: the 1st group received saline normal (ip) (control group); the 2nd group received Carboxymethylcellulose (CMC) 0.5% (ip) (vehicle group) and the next groups received, respectively different doses of Carprofen (5, 10, 20, 40, 60, 80 and 100 mg kg<SUP>-1</SUP> ip) 45 min before determination of seizure threshold induced by PTZ. Results showed that PTZ-induced seizure threshold in control mice was 34.75&plusmn;1.54 mg kg<SUP>-1</SUP>. Intraperitoneal injection of Carprofen showed significant (p&lt;0.05) increase of PTZ-induced seizure threshold in a dose dependently manner compared with control group. According to the results, Carprofen has anticonvulsant effects on mice. Nevertheless, new studies must be carried out in order to determine the beneficial effects of NSAIDs in treatment of epilepsy.
ER  -