TY  - JOUR
T1  - Antibacterial and Antifungal Activity of <I>Commiphora swynnertonii</I> (Burt) Against Selected Pathogens of Public Health Importance
AU - Max, R.A. AU - Bakari, G.G. AU - Mdegela, H.R. AU - Phiri, E.C. AU - Mtambo, M.M. 
JO  - Research Journal of Biological Sciences
VL  - 6
IS  - 4
SP  - 175
EP  - 179
PY  - 2011
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2011.175.179
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2011.175.179
KW  - Commiphora swynnertonii
KW  -antibacterial activity
KW  -antifungal
KW  -cytotoxicity test
KW  -crude plant extracts
KW  -bacteria
AB  - Ethanolic extracts from different morphological parts of the tropical tree, <I>Commiphora swynnertonii</I> were tested against fungi and bacteria using agar well diffusion method. The fungi included <I>Candida albicans</I> and <I>Aspergillus niger </I>whereas the bacteria species included <I>Staphylococcus aureus</I>,<I> Streptococcus pyogenes</I>,<I> Bacillus subtilis</I>,<I> Pseudomonas aeruginosa</I>,<I> Salmonella typhimurium</I> and <I>Escherichia coli</I>. Antimicrobial activity was determined by measuring inhibition zone diameters around agar wells. Among the four tested morphological parts, resin and root bark extracts showed significant activities against <I>S. pyogenes</I>,<I> E. coli </I>and<I> B. subtilis </I>compared to the other two extracts. The growth of <I>E. coli</I> was highly reduced by resin extract (minimum inhibition concentration = 1.9 mg mL<SUP>-1</SUP>). The fungi, <I>C. albicans</I> also showed similar sensitivity to resin and root bark extract. Growth of <I>S. typhimurium</I> was not reduced by all four extracts at all concentrations tested whereas that of <I>P. aeruginosa</I> was slightly reduced. Cytotoxicity studies using brine lethality test indicated that root bark, stem bark and resin extract had effect to brine shrimps with LC<SUB>50</SUB> of 3.5, 13.0 and 15.8 &#956;g mL<SUP>-1</SUP>, respectively. The current results indicate that resin and root bark extracts of <I>C. swynnertonii</I> have strong antimicrobial activity against most of the tested microbes and support the traditional use of the plant in treating various infectious diseases. Further studies are suggested to validate the use of this plant against the diseases caused by the tested microbes.
ER  -