TY  - JOUR
T1  - Anxiolytic Effect of <I>Echium amoenum</I> During Different Treatment Courses
AU - , S. Gholamzadeh AU - , S. Zare AU - , M. Ilkhanipoor 
JO  - Research Journal of Biological Sciences
VL  - 3
IS  - 2
SP  - 176
EP  - 178
PY  - 2008
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2008.176.178
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2008.176.178
KW  - Echium amoenum
KW  -aqueous extract
KW  -anxiolytic
KW  -elevated plus maze
AB  - <I>Echium amoenum</I> (Boraginaceae) is a very popular medicinal plant which is used as a tonic, tranquillizer, diaphoretic, cough remedy, sore throat and pneumonia in Iran<SUP>`</SUP>s traditional medicine. Preliminary phytochemical study of the plant, with standard procedures, showed that it contains saponins, flavonoids, unsaturated terpenoids and sterols. There was no evidence of tannins, alkaloids and cyanogenic glycosides. In this study an aqueous extract from petals of this botanical was used in 125 mg kg <SUP>1</SUP> concentration as compared with diazepam 1 mg kg <SUP>1</SUP> intraperitonealy (i.p.), during  2  different treatment courses, 15 and  30 days. Anxiolytic effect of extract was investigated in Rat using the elevated plus maze model of anxiety. After finishing these courses and 30 min after last injections, the test performed. Results revealed that in 30 days treatment course, time spent in open arms was significantly higher than 15 days treatment in all groups and this effect is lower than diazepam. So we showed a significant time-dependent increase in time spent in open arm.
ER  -