TY  - JOUR
T1  - The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of <I>Plasmodium berghei</I> and <I>Plasmodium falciparum</I>
AU - , Marianne Patricia Ntsama epse Foh Mengo AU - , Giampietro Corradin AU - , Silayuv Bongfen 
JO  - Research Journal of Biological Sciences
VL  - 3
IS  - 12
SP  - 1446
EP  - 1451
PY  - 2008
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2008.1446.1451
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2008.1446.1451
KW  - Evaluation
KW  -immune response
KW  -circumsporozoite (CSP)
KW  -plasmodium berghei
KW  -plasmodium falciparum
AB  - Malaria infection is initiated when an infected Anopheline mosquito injects sporozoites during a blood meal. The Circumsporozoite (CSP) protein is the major surface protein of plasmodium sporozoites and forms a dense coat on the parasite’s surface. Although, the C-terminal (Ct) portion or side of the CSP protein has been extensively studied as a malaria candidate vaccine, little is known about the N-terminal (Nt) portion and the mixture of the 2 portions (Nt + Ct) of this protein on the immune response. Our data suggest that the mixture (Nt + Ct) peptides responded well and much more better inhibition of invasion of hepatocytes was given by the use of that mixture than when Ct or Nt was used separately. The 2 peptides seem to play an important inhibitory role against the invasion of hepatocytes by sporozoites.
ER  -