TY  - JOUR
T1  - No Association of <I>BglI</I> Dimorphism of Human Renin Gene in Hypertensive Subjects in Malaysia
AU - , R. Vasudevan AU - , Patimah Ismail AU - , Johnson Stanslas AU - , Norashikin Shamsudin 
JO  - Research Journal of Biological Sciences
VL  - 3
IS  - 10
SP  - 1218
EP  - 1222
PY  - 2008
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2008.1218.1222
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2008.1218.1222
KW  - Essential Hypertension
KW  -Type 2 Diabetes Mellitus
KW  -Renin
KW  -BglI dimorphism
KW  -PCR-RFLP
AB  - The presence of a dimorphic <I>BglI</I> site in the first intron of the Renin (REN) gene is an increased risk in essential hypertension. Several studies have found the association between <I>BglI</I> dimorphism and essential hypertension with conflicting results in various populations, which might be due to ethnic and geographical variations. The objective of this study is to determine the relationship between the <I>BglI</I> dimorphism of REN gene and Essential Hypertension (EHT) with or without Type 2 Diabetes Mellitus (T2DM) in Malaysian subjects. The study includes 70 EHT, 60 EHT with T2DM and 70 unrelated healthy subjects from the three ethnic groups of Malaysian Subjects. The genotype of <I>BglI</I> dimorphism was done by PCR-RFLP method using <I>BglI</I> restriction enzyme. The frequency of the <I>BglI</I> (+) allele was 37.86% in EHT, 40.83% in EHT with T2DM subjects and 35.71% in control subjects. The results of this study indicate that the <I>BglI</I> (+) allele of REN gene is not associated with essential hypertension with or without T2DM in Malaysian Subjects.
ER  -