TY  - JOUR
T1  - Influence of Subcutaneous Indole-3-Acetic Acid Administration in Metabolism and Function of the Rat Leukocyte
AU - , Mariza P. de Melo AU - , Natalia F. Franco AU - , Mariana S.L. Ferreira AU - , Silvana M.P. Pugine AU - , Poliana P. Briato AU - , Ernane J.X. Costa 
JO  - Research Journal of Biological Sciences
VL  - 2
IS  - 5
SP  - 601
EP  - 606
PY  - 2007
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2007.601.606
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2007.601.606
KW  - IAA
KW  -plant growth regulation
KW  -ripening
KW  -neutrophil
KW  -lymphocyte
KW  -enzyme activity
AB  - Indole-3-Acetic Acid (IAA) is a naturally occurring auxin, well known for its regulatory function in plant growth and its association with fruit ripening and senescence. This study aimed to investigate the effect of IAA administration on leukocytes metabolism and function. This growth plant hormone promoted a decrease in glucose oxidation (20%) by neutrophils and an increase in glutamine consumption (31%) by these cells, but no alteration was shown on consumption of the glucose and glutamine by lymphocytes. IAA did not cause a marked effect on the key enzyme activities of glucose and glutamine metabolism in neutrophils or lymphocytes. The IAA treatment did not show alteration of the phagocytic parameters of <I>Staphyloccocus aureus </I>engulment by neutrophils, with bacteria killed by myeloperoxidase activity in these cells, compared with the control animals. The observations presented led us to conclude that administration of subcutaneous IAA promotes an alteration in the rat’s neutrophil metabolism, deduced by a decrease in glucose consumption and an increase in glutamine consumption in neutrophils; suggesting that the alteration of glucose metabolism could be compensated for by glutamine utilization in these cells. The metabolism alteration in rat neutrophils does not reduces the phagocytic capacity or myeloperoxidase activity of this cell. The effect of IAA administration, similar to <I>in vitro</I> studies, may reflect the reaction between IAA and myeloperoxidase.
ER  -