TY  - JOUR
T1  - Effect of Vitamin C on Cyproterone Acetate Induced Genotoxic Damage in Mice
AU - , Yasir Hasan Siddique AU - , Gulshan Ara AU - , Tanveer Beg AU - , Mohammad Afzal 
JO  - Research Journal of Biological Sciences
VL  - 1
IS  - 1
SP  - 69
EP  - 73
PY  - 2006
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2006.69.73
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2006.69.73
KW  - Cyproterone acetate
KW  -vitamin c
KW  -chromosomal aberrations
KW  -sister chromatid exchanges
KW  -mice bone marrow cells
AB  - The genotoxicity study of cyproterone acetate was carried out in mouse bone marrow cells using Sister Chromatid Exchanges (SCEs) and Chromosomal Aberrations (CAs) as a parameter. The effect of cyproterone acetate was studied at 6.25, 12.50 and 25.00 mg kg<SUP>-1</SUP> of body weight and was found to be genotoxic at 12.50 and 25.00 mg kg<SUP>-1</SUP> of body weight. Further the effect of vitamin C on 25.00 mg kg<SUP>-1</SUP> of body weight of cyproterone acetate was also studied. Three doses of vitamin C i.e. 20, 40 and 60 mg kg<SUP>-1</SUP> of body weight were given along with 25.00 mg kg<SUP>-1</SUP> of body weight of cyproterone acetate. Treatments along with vitamin C results in a significant decrease in CAs and SCEs suggesting an antigenotoxic role of vitamin C against cyproterone acetate induced genotoxic damage in mice bone marrow cells.
ER  -