TY  - JOUR
T1  - CTLH: A Novel Domain with A Typical "U" Shape Architecture
AU - , Weiqi Zeng AU - , Yuequn Wang AU - , Wuzhou Yuan AU - , Yun Deng AU - , Yongqing Li AU - , Chuanbing Zhu AU - , Mingyao Liu AU - , Xiushan Wu 
JO  - Research Journal of Biological Sciences
VL  - 1
IS  - 1
SP  - 12
EP  - 15
PY  - 2006
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2006.12.15
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2006.12.15
KW  - CTLH domain
KW  -3D architecture
KW  -signaling pathways
KW  -living activities
AB  - We described here a novel domain, CTLH, which can be found in proteins of most already-researched species  currently.  The  domain,  consisted  of  58  amino  acid  residues, is not often-conserved in sequence (but has 5 regularly-arranged leucines that are highly conserved).  However, its 3D architecture conserves greatly with a typical ´U´ shape (alpha helix+beta turn+alpha helix).  Although the function of CTLH domain remains unknown, related studies aiming at this domain suggest it participates in the regulation of certain signaling pathways like MAPK, and is involved in some living activities of cells such as protein degradation and mitosis.
ER  -