TY  - JOUR
T1  - Pathological Studies of Various Levels of Dietary
<i>Momordica charantia</i> on Wistar Rats
AU - Al-Hizab, Fahad Abdullah AU - Moqbel, Mohammed Salem AU - Barakat, Seif Mustafa 
JO  - Journal of Animal and Veterinary Advances
VL  - 16
IS  - 2
SP  - 43
EP  - 47
PY  - 2017
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2017.43.47
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2017.43.47
KW  - Clinicopathology
KW  -histopathology
KW  -hepatotoxicity
KW  -Momordica charantia
KW  -nephrotoxicity
AB  - The study aimed to evaluate the pathological, haematological and biochemical effects of various
levels of dietary<i> Momordica charantia</i> (MC) in male Wistar rats.<i> Momordica charantia</i> (MC) is claimed to
have several medicinal properties and is used as a traditional medicine for the treatment of a wide variety of
disorders. The fruits of MC was fed to rats at 2, 5 and 10% of the standard diet for a period of 3 months.
Administration of MC fruits at 2 and 5% was not toxic to rats. However, focal cellular swelling and individual
cell necrosis of hepatocytes as well as degenerative changes in the renal tubules associated with interstitial
nephritis were observed in rats fed with a diet containing 10% MC. These histopathological changes were
accompanied clinically by alteration of serum Aspartate aminotransferase (AST), Alanine aminotransferase
(ALT), Alkalin Phosphatase (ALP), BUN, creatinine and uric acids. No significant changes were observed in
hematological values in all groups.
ER  -