TY  - JOUR
T1  - Hepatoxicity Induced by Glyphosate-Based Herbicide Baron in Albino Rats
AU - N. Danial, Enas AU - E.A. Elhalwagy, Manal AU - Amin Abdulmagid, Nadia AU - S. Alnahdi, Hanan 
JO  - Journal of Animal and Veterinary Advances
VL  - 13
IS  - 5
SP  - 322
EP  - 329
PY  - 2014
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2014.322.329
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2014.322.329
KW  - Glyphosate
KW  -liver toxicity
KW  -oxidative stress
KW  -DNA damage
KW  -commet assay
AB  - Baron is herbicide includes (48% glyphosate) widely used in Egypt. The present study assess cytotoxic and genotoxic effect of Baron on rats liver. Two groups of rats were treated orally with 1/10 LD<SUB>50</SUB> (275.49 mg kg<SUP>-1</SUP>) and 1/40 LD<SUB>50</SUB> (68.86 mg kg<SUP>-1</SUP>) glyphosate for 28 days compared with control group. Serum and liver tissues were taken at 14 and 28 days of treatment. An inhibition in Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) activites were recorded at both treatment periods and reduction in Total serum Protein (TP) and Albumin (ALB). However, non-significant changes in serum Acetylcholinesterase (AChE). Elevation in oxidative stress biomarker Malondyaldehyde (MDA) and decline in detoxification biomarkers total reduced Glutathione (GSH), Glutathione S-Transferase (GST) and Superoxide Dismutase (SOD) in liver tissue led to increase in percentage of DNA damage. Destruction in liver tissue architecture was observed. Although, Baron was classified in the safe category pesticides repeated exposure to small doses has great danger effect.
ER  -