TY  - JOUR
T1  - Kinetics of Interleukin-17 and Interleukin-17Associated Cytokines in Sera and Milk in Dairy Goat Mastitis Experimentally Induced with <I>Escherichia coli</I>
AU - Liu, Hui AU - Mou, Shan AU - Cao, Duoyao AU - Jing, Xiaoqi AU - Han, Yansen AU - Yao, Jing AU - Zhao, Lijuan AU - Zhao, Yanqing AU - Shang, Chuanchang AU - Chen, Dekun 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 5
SP  - 597
EP  - 602
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.597.602
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.597.602
KW  - Dairy goat
KW  -IL-17
KW  -mastitis
KW  -proinflammatory cytokines
KW  -milk
KW  -cell
AB  - IL-17 is a crucial mediator of mucosal inflammation for extracellular bacteria clearance. The production of IL-17 was associated with TGF-&#946; and multiple proinflammatary cytokines, especially IL-6 and IL-1&#946;. IL-17 can cooperate additively or synergistically with IL-6 or IL-1&#946; to amplify of inflammatory processes. However, the roles of IL-17 and cytokines associated with IL-17 in dairy goat mastitis is poorly understood. In the present study, the concentrations of IL-17, IL-6, IL-1&#946; and TGF-&#946; were assayed in sera and milk of Guanzhong dairy goat mastitis induced with <I>Escherichia coli</I> using the Enzyme-Linked Immunosorbent Assay (ELISA) at several time points before and after challenge. The results showed that the levels of all cytokines varied slightly in sera while raised significantly in milk post intramammary inoculation with <I>E. coli</I>. The results suggest that IL-17 is one of important mediators in mammary gland inflammation for bacterial clearance in dairy goat mastitis and IL-6 and TGF-&#946; play an important role or help for development in IL-17 producing cells in goat.
ER  -