TY  - JOUR
T1  - Useful Marker Around <I>TRDN</I> Gene Showing Marbling-Associated Expression Changes
AU - Yamada, Takahisa AU - Tong, Bin AU - Muramatsu, Youji AU - Yamamoto, Takuji AU - Tanomura, Hideki AU - Ohta, Takeshi AU - Kose, Hiroyuki AU - Sugiyama, Toshie 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 15
SP  - 2792
EP  - 2795
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2792.2795
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2792.2795
KW  - Allelic distribution
KW  -TRDN
KW  -close marker
KW  -marbling
KW  -single nucleotide polymorphism
KW  -Japan
AB  - Researchers have previously showed that the <I>triadin</I> (<I>TRDN</I>) gene involved in muscle contraction possesses expression differences in musculus longissimus muscle between low-marbled Holstein and high-marbled Japanese Black steer groups. In the present study, researchers found that a marker (BMS817) close to the TRDN was polymorphic between low-marbled Holstein and high-marbled Japanese Black steer groups and exhibited significantly different allelic distribution between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. Further, researchers detected Single Nucleotide Polymorphism (SNP) in the <I>TRDN</I> gene between low-marbled Holstein and high-marbled Japanese Black steer groups. The allelic distribution of the SNP referred to as g.3834941C&gt;T in the TRDN was indistinguishable between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. The findings suggest that an unidentified true causal mutation which is in linkage disequilibrium with the BMS817 marker but not the g.3834941C&gt;T SNP may be related to changes in <I>TRDN</I> gene expression and/or marbling. The BMS817 marker may be useful for effective marker-assisted selection to increase the levels of marbling.
ER  -