TY  - JOUR
T1  - Bioinformatics Analysis of Melanocortin-1 Receptor Gene for Silver Fox and Other Species
AU - Gong, Yuan-Fang AU - Zhao, Jun-Sheng AU - Su, Yong-Mei AU - Ge, Mu-Xiang AU - Duan, Ling-Xin AU - Zhu, Wen-Jin AU - Feng, Min-Shan AU - Liu, Zheng-Zhu 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 7
SP  - 1000
EP  - 1006
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1000.1006
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1000.1006
KW  - variation
KW  -silver fox
KW  -CDS
KW  -MC1R gene
KW  -species
KW  -China
AB  - The <I>MC1R</I> gene plays an important role in pigment synthesis in many species including human being. In the study, the coding sequence of the silver fox <I>MC1R</I> gene was obtained by the method of PCR direct sequencing and aligning, the length was 954 bp. A total of 119 <I>MC1R</I> gene sequences with the complete Coding regions (CDS) belonging to 23 species were analyzed and the differentiation within and among the species was also studied. The results showed that most of the species have the stop codon TGA. Only <I>Gallus gallus</I> and <I>Cereopsis novaehollandiae </I>of Phasianidae and <I>Danio rerio</I>, respectively used TAG and TAA as the stop codon. The length of the <I>MC1R</I> gene with the complete CDS varies greatly, from 924-972 bp but most of the species had 954 bp. Observed genetic diversity was higher among species than within species and <I>Canis lupus familiaris</I> had more polymorphisms than any other species. Differentiation of the <I>MC1R</I> gene was obvious among species and the reconstructed phylogenetic tree was basically consistent with the taxonomy in the National Center for Biotechnology Information.
ER  -