TY  - JOUR
T1  - A Comprehensive <I>in silico</I> Analysis of Functional and Structural Impact SNPS in the <I>MC1R</I> Gene
AU - Zhang, Chuan-Sheng AU - Geng, Li-Ying AU - Liu, Zheng-Zhu AU - Fu, Zhi-Xin AU - Gong, Yuan-Fang AU - Feng, Min-Shan AU - Juan, Chen AU - Jia, Qing-Hui AU - Wang, Qiu-Yue AU - Liu, Xie-Rong AU - Pan, Su-Min 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 7
SP  - 928
EP  - 931
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.928.931
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.928.931
KW  - MC1R
KW  -MC1R
KW  -SIFT
KW  -PolyPhen
KW  -PolyPhen
KW  -PolyPhen
AB  - The aim of this study was to analyze the genetic variation that can alter the expression and the function of the <I> MC1R</I> gene using computational methods. Out of the total 222 SNPs, 22 were found to be non-synonymous (ns) SNPs, 9 were found in the 5' upstream and 7 were found in the 3'UTR. It was found that these 6 nsSNPs rs3212366, rs11547464, rs1805009, rs1805008 and rs1805007 were damaging by both the SIFT and the Poly Phen servers. We identified, a mutation from Phe to Leu at positions 196 (rs3212366) on the surface of the protein caused the greatest impact on stability. The rs3212362, rs3212379 and rs35025176 in the 5' upstream were suggested might change the <I>MC1R</I> gene expression levels by FastSNP. Based on the <I>in silico</I> search, the rs3212369 located in the putative Hsa-miR-421 target sequences might have some effect on <I>MC1R</I> gene expression.
ER  -