TY  - JOUR
T1  - The Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on the Levels of Malondialdehyde, Reduced Glutathione and Nitric Oxide in the Lung, Liver and Kidney Tissues in Acute Diazinon Toxicity in Rats
AU - Alp, Harun AU - Aytekin, Ismail AU - Atakisi, Onur AU - Hatipoglu, Namik Kemal AU - Basarali, Kemal AU - Ogun, Metin AU - Buyukbas, Sadik AU - Altintas, Levent AU - Ekici, Husamettin AU - Alp, Ayse 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 11
SP  - 1488
EP  - 1494
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.1488.1494
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.1488.1494
KW  - Caffeic acid phenethyl ester
KW  -diazinon
KW  -ellagic acid
KW  -malondialdehyde
KW  -nitric oxide
KW  -reduced glutathione
AB  - The aim of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) and Ellagic Acid (EA) on acitivities of Malondialdehyde (MDA), reduced Glutathione (GSH) and Nitric Oxide (NO) in rat lung, liver and kidney tissues in acute Diazinon (DI) toxicity. Six groups of 6 Sprague Dawley rats were used comprising control, CAPE, EA, DI control, DI+CAPE and DI+EA. Tissue samples were analysed for GSH, MDA and NO levels in lung, liver and kidney tissues. Biochemical parameters were measured colormetrically by spectrophotometer. Control, CAPE and EA groups showed no statistically significant difference whereas DI+medication groups revealed that CAPE and EA increased the level of GSH in liver tissue by blocking the DI effect. NO levels in lung, liver and kidney tissues were significantly increased by DI but CAPE and EA attenuated those levels. In DI+medication groups, MDA levels showed no significant change in kidney and liver tissues but in lung tissues, CAPE and EA reduced the MDA level by blocking the DI effect. It was concluded that CAPE and EA which showed similar effects to each other could be used for protection and support against oxidative stress caused by acute DI intoxication.
ER  -