TY  - JOUR
T1  - The Effect of Oxfendazole+Oxyclozanide Paste and Tablet Formulations on Parasite Burden and Metabolic Status of Sheep
AU - , V. Gunes AU - , A. Inci AU - , F. Uyanik AU - , A. Yildirim AU - , N. Altug AU - , M. Eren AU - , A.C. Onmaz AU - , C.C. Gelfert 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 5
SP  - 589
EP  - 594
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.589.594
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.589.594
KW  - Sheep
KW  -oxyclozanid-oxfendazole
KW  -endoparasite
KW  -treatment
KW  -micro mineral
AB  - The aim of the present study was to evaluate the effects of anthelmintic treatment with Oxyclozanid + Oxfendazole in different formulation (paste and tablet) on parasite load and metabolic status in sheep. Forty five sheep, infected with various gastrointestinal parasites and kept on a grazing flock, were evenly divided into 3 groups. Sheep in the control group did not receive any treatment. The sheep in the remaining groups received the same dose of Oxyclozanid (5 mg kg <SUP>1</SUP> body weight) and Oxfendazole (13.5 mg kg <SUP>1</SUP> body weight) in combination either as tablet or as paste. Faeces and blood samples were collected pre-treatment (day 0) and on day 14 post-treatment. Several gastrointestinal nematode parasites were detected in the faecal samples. Eggs Per Gram (EPG) on days 0 and 14 were 100±18 and 78±8 in CG, 96±12 and 6±3 in TG and 76±9 and 2±2 in the PG, respectively. Serum total protein and globulin concentrations increased significantly (p&lt;0.05) in CG and PG on day 14 compare to pre-treatment levels. In both sampling times total protein levels did not differ whereas a slight decrease in paste group and a significant decrease in tablet group were detected concerning globulin level, but no significant difference was detected between the tablet group and paste group on day 14 post-treatment. In paste group serum albumin level increased (p&lt;0.05) on day 14 compare to baseline level. Compare to control group, albumin level slightly increased in tablet group, whereas it significantly increased in paste group on day 14 post-treatment. On day 14 in paste group Pi, Mg and Cu levels were higher (p&lt;0.05) than the post-treatment levels of the remaining groups. A combination of Oxyclozanid+Oxfendazole is effective to eliminate parasite burden in sheep. Drug formulation does not have any influence on the metabolic status of the sheep.
ER  -