TY  - JOUR
T1  - Efficacy of <I>Peltophorum africanum</I> Sond. (Fabaceae) Extracts on <I>Haemonchus contortus</I> and <I>Trichostrongylus colubriformis</I> in Sheep
AU - , E.S. Bizimenyera AU - , S. Meyer AU - , V. Naidoo AU - , J.N. Eloff AU - , G.E. Swan 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 4
SP  - 364
EP  - 371
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.364.371
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.364.371
KW  - Efficacy
KW  -safety
KW  -sheep
KW  -extracts
KW  -Trichostrongylus colubriformis
KW  -Haemochus contortus
KW  -Peltophorum africanum
AB  - The search for sustainable and easily affordable herbal medicines is on worldwide, prompted by emergency of anthelmintic resistance. Following substantially positive <I>in vitro</I> research, the efficacy and safety of extracts of <I>Peltophorum africanum</I> was determined against the parasitic gastrointestinal nematodes in sheep<I>.</I> Twenty four weaned male Dorper lambs were induced with infections (L<SUB>3</SUB> infective stages) of <I>Haemonchus contortus</I> (2,800 each) and <I>Trichostrongylus colubriformis </I>(3,500 each). Four weeks later, the sheep were dosed with acetone extracts of <I>P. africanum </I>at doses of 50, 500 and 750 mg kg <SUP>1</SUP>. The control group received no treatment.  There  was  no  significant  (p = 0.073)  faecal  egg  counts  reductions  at  concentrations  of  up to 750 mg kg <SUP>1</SUP>, or reduction in total worm burden. However, the extracts showed no deleterious effects on the sheep. Feed consumption remained the same for both treated and untreated controls. Further research on appropriate dosage form or on isolation of effective anthelmintic compounds from <I>P. africanum</I> is called for.
ER  -