TY  - JOUR
T1  - Effects of Sevoflurane and Desflurane on Oxidant/Antioxidant Status of Young Versus Old Rat Liver Tissues
AU - , Arslan Mustafa AU - , Isik Berrin AU - , Unal Yusuf AU - , Nihan Nurlu AU - , Ozkose Zerrin AU - , Comu Faruk Metin AU - , Gunes Isin AU - , Demirel Cengiz Bekir AU - , Cekmen Nedim AU - , Kavutcu Mustafa AU - , Kurtipek Omer 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 11
SP  - 1345
EP  - 1351
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.1345.1351
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.1345.1351
KW  - Oxidative stress
KW  -desflurane
KW  -sevoflurane
KW  -rat
KW  -age
AB  - Anesthetic agents modulate on oxidant/antioxidant activity. This study aimed to evaluate the effects of desflurane and sevoflurane anesthesia on the oxidant/antioxidant activity in the liver of young and aged rats. The  study  involved 60 male Wistar Albino Rats. Rats, which 5-6 months of age deemed as young (Group Y, n = 30) and 10-11 months of age deemed as old (Group O, n = 30). The weight range of the rats was 270-350 g. The groups of rats were randomly divided into 3 groups as the control group [Group Y<SUB>C</SUB> (Young Control 100% O<SUB>2</SUB>; n = 10) and Group O<SUB>C</SUB> (Old Control 100% O<SUB>2</SUB>; n = 10)], desflurane group [Group Y<SUB>D</SUB> (Young Desflurane; 6% Desflurane in 100% O<SUB>2</SUB>; n = 10)] and Group O<SUB>D</SUB> (Old Desfluranee; 6% Desflurane in 100% O<SUB>2</SUB>; n = 10)] and sevoflurane  group  [Group  Y<SUB>S</SUB>  (Young  Sevoflurane;  2%  Sevoflurane  in  100%  O<SUB>2</SUB>;  n  =  10) and Group O<SUB>S</SUB> (Old Sevoflurane; 2% Sevoflurane in 100% O<SUB>2</SUB>; n = 10)]. The rats placed into a transparent plastic cage. The rats were exposed to different anesthetic agents or oxygen for 2 h by the use of half  open  Anesthesia  System (AMS, Senior 425), while rats’ simultaneous normal breathing was maintained. At the end of the exposure, they were administered a high dose of ketamine and the livers of the animals were sugically removed. SOD, GST and NOS activities were determined and levels of oxidative stress was monitored by measuring TBARS via levels of MDA in the liver. Desflurane induce oxidative stress in both young and old rats, with higher levels in old rats. However, sevoflurane did not cause oxidative stress in young rats. Sevoflurane increased the oxidative stress in the old rats based on SOD and TBARS levels, while it maintained GST activity and decreased NOS activity. However, further studies are needed.
ER  -