TY  - JOUR
T1  - Intracerebroventricular Injection of L-Proline Modifies Food Intake in Neonatal Chicks
AU - , T. Haraguchi AU - , S. Tomonaga AU - , I. Kurauchi AU - , K. Hamasu AU - , H. Sato AU - , D.M. Denbow AU - , M. Furuse 
JO  - Journal of Animal and Veterinary Advances
VL  - 6
IS  - 11
SP  - 1255
EP  - 1257
PY  - 2007
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2007.1255.1257
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2007.1255.1257
KW  - L-Proline
KW  -food intake
KW  -feeding condition
KW  -intracerebroventricular injection
KW  -neonatal chick
AB  - Although, the central function of amino acids on food intake has been investigated, little information is available on the role of the amino acid L-proline. To clarify the central effect, several doses (0, 0.25, 0.5 and 1.0 mg) of L-proline were intracerebroventricularly (i.c.v.) injected into chicks under fasting (3 h) or ad libitum feeding conditions. Food intake was determined through 60 min post injection. Under fasting conditions, the following  regression  equation  was obtained: food intake (g) = 3.047 + 3.496x – 5.332 x<SUP>2</SUP> (x in mg of L-proline, R<SUP>2</SUP> = 0.466, RMS = 1.056). Similarly, the regression equation was obtained under ad libitum conditions as follows: food intake (g) = 0.479 (SE 0.164) + 2.130 (SE 0.815)x – 2.452 (0.747)x<SUP>2</SUP> (R<SUP>2</SUP> = 0.313, RMS = 0.487). These results indicated that food intake was mildly stimulated by low levels of L-proline, but was suppressed by high levels in chicks. It is suggested that L-proline may act in the central nervous system to differentially regulate food intake, depending upon dose.
ER  -