TY  - JOUR
T1  - <I>In vivo</I> and <I>in vitro</I> Immunmodulatory Activities of <I>Nerium oleander</I> Aqueous Leaf Extract in Rabbits
AU - , M.I. Al-Farwachi 
JO  - Journal of Animal and Veterinary Advances
VL  - 6
IS  - 9
SP  - 1047
EP  - 1050
PY  - 2007
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2007.1047.1050
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2007.1047.1050
KW  - In vivo
KW  -immunmodulatory activities
KW  -leaf extract
KW  -rabbit
AB  - The <I>in vitro</I> effect of <I>Nerium oleander </I>(NO) aqueous leaf extract on humoral and phagocytic activity and <I>in vivo</I> cellular immune response were studied in rabbits. Treatment of rabbits with the extract at 75 mg kg <SUP>1</SUP> body  weight  subcutaneously  not  only  diminished  the  production of antibodies, but also exerted an inhibition on delayed type hypersensitivity reaction and phagocytic activity, whereas treatment of rabbits at 50 and 25 mg kg <SUP>1</SUP> body weight subcutaneously caused stimulation of the immune system. These results suggest the NO aqueous leaf extract exerts a marked immunomodulatory effect on the rabbits, immune system.
ER  -