TY  - JOUR
T1  - Prevention of Acute Gastric Mucosal Lesions by <I>R. Hasseltii</I> in Rats
AU - , Noor, S.M. AU - , A.A. Mahmood AU - , I. Salmah AU - , K. Philip 
JO  - Journal of Animal and Veterinary Advances
VL  - 5
IS  - 2
SP  - 161
EP  - 164
PY  - 2006
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2006.161.164
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2006.161.164
KW  - Cytoprotection
KW  -rate
KW  -Rafflesia hasseltii
KW  -cimetidine
AB  - Cytoprotective effects are important in preventing the formation of gastric mucosa necrosis. <I>Rafflesia hasseltii</I>, used in traditional aboriginal Malay treatment of postpartum women, was evaluated for its cytoprotective effects. Both aqueous and ethanol extracts of the plant were evaluated to determine which extract offers better protection of the gastric mucosa  in  terms  of  inhibiting  ulcer damage. Gastric ulcers were induced by oral administration of absolute ethanol (5mL kg<SUP>-1</SUP>) to 4 groups of fasting rats: the ulcer control rats which  received  no  pre-treatments  (Group  1);  rats  pre-treated with oral aqueous extracts of <I>R. hasseltii </I>(Group 2); rats pre-treated with oral ethanolic extracts of <I>R. hasseltii</I> (Group 3) and rats pre-treated with oral cimetidine (Group 4).<I> </I>Oral pre-treatments were given 30 minutes prior to oral induction of ulcers by absolute alcohol. Animals in Group 1 experienced severe gastric damage following absolute ethanol administration, with absolutely no inhibition. Group 2 and Group 3 rats exhibited the highest degree of inhibition to ethanol-induced ulcer  damage,  by  a  percentage  99.2  and  98.9%  inhibition,  respectively.  Animals  in  Group  4,  the cimetidine group, had only 59.4% inhibition to ethanol-induced gastric damage. The results suggested that <I>R. hasseltii</I> possess  novel  cytoprotective  activity  on  gastric  mucosal  cells  and  undeniably  beneficial  for  treating gastric ulcer.
ER  -