TY  - JOUR
T1  - Glucomannan as a Dietary Ergot Alkaloid Adsorbent for Mares
AU - , I.O. Adam AU - , B.J. Rude AU - , P.L. Ryan AU - , D.L. Christiansen AU - , N.M. Filipov AU - , Veysel Akay AU - , N.S. Hill AU - , B.P. Fitzgerald 
JO  - Journal of Animal and Veterinary Advances
VL  - 5
IS  - 12
SP  - 1242
EP  - 1250
PY  - 2006
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2006.1242.1250
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2006.1242.1250
KW  - Endophyte
KW  -ergot alkaloid
KW  -glucomannan
KW  -mare
KW  -tall fescue
AB  - Glucomannan modified for greater ergot alkaloid affinity was fed to mares to evaluate its efficacy as a dietary ergot alkaloid adsorbent. Mares were fed bermudagrass hay along with one of four feed mixtures containing either endophyte-free (E-) or toxic endophyte-infected tall fescue seed. All rations based on toxic endophyte-infected tall fescue seed contained 1.69 ppm ergot alkaloids on a dry matter (DM) basis. Modified GLMN was provided at 0 (E+), 5 (E+5), or 10 g (E+10) twice daily. Efficacy of ergot alkaloid adsorption by GLMN was evaluated by measuring alkaloid consumption vs. fecal and urine excretion. Blood metabolites and hormones were evaluated as physiological indicators of ergot elimination. Hay and total DM intake (DMI) was not affected (p = 0.59) and ranged from 1.17 to 1.33 and 2.0 to 2.15% BW/d, respectively. Ergot alkaloid concentrations in feces (p = 0.02; 31.02 to 225.53 ng g<SUP>-1</SUP>) and urine (p &lt; 0.01; 0.96 to 37.12 ng mg<SUP>-1</SUP> creatinine) were greater for mares receiving E+, E+5, or E+10 than E- and supplemental GLMN did not alter urinary ergot alkaloid  excretion.  No differences were found within treatment phase for plasma 3,4-dihydroxyphenylacetic acid (DOPAC; p = 0.24; 4.94 to 8.68 ng mL<SUP>-1</SUP>), serum cortisol (p = 0.14; 4.48 to 5.69 &#956;g dL<SUP>-1</SUP>), or PRL (p = 0.40; 2.89 to 3.85 ng mL<SUP>-1</SUP>). Findings are inconclusive and further investigation is needed to determine the efficacy of feeding modified GLMN to mares grazing toxic endophyte-infected tall fescue pastures.
ER  -