TY  - JOUR
T1  - Effect of Dexamethasone Treatment on the Hematological and Histological Parameters of Mice Following Experimental Bacterial Infection
AU - , Salmah Ismail AU - , Son Radu AU - , Khalifah Sidek AU - , Mohd Azhar Arifffin AU - , Mohammad Nazmul Hasan Maziz AU - , Irwan Hamzah AU - , Mahmood Ameen Abdulla 
JO  - Journal of Animal and Veterinary Advances
VL  - 2
IS  - 4
SP  - 231
EP  - 236
PY  - 2003
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2003.231.236
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2003.231.236
KW  - 
AB  - There are four groups of balb/c mice with each of it consists of 6 animals. Group 1, 2 and 3 were injected with dexamethasone daily for three days and experimentally infected with Pasteurella multocida, Escherichia coli harboring a recombinant plasmid ABA392 and Staphylococcus aureus respectively. Whereas, group four serve as control. At 24, 48 and 72 hours post-infection a marked increase in total leucocytes counts while differential leucocytes count revealed a marked increase in neutrophils and decrease in lymphocytes and monocytes in all dexamethasone-treated animals and was more predominant in group 1 and 2 post infection in all animals. At 72 hours post-infection, the histological examination reveals haemorrhagic (hemorrhagic septicaemia) features of lungs in dexamethasone-treated mice and infected with P. multocida and the recombinant plasmid ABA392 but not with the dexamethasone-treated and infected with S. aureus indicate that recombinant plasmid ABA392 may harbor a sequence that may code for virulent factor of Pasteurella multocida.
ER  -