@article{MAKHILLAJ202116320728,
    title = {Formulation and Evaluation of Mucoadhesive Microspheres of Cimetidine for its Gastro
Retentive Drug Delivery Efficacy},
    journal = {Agricultural Journal},
    volume = {16},
    number = {3},
    pages = {34-40},
    year = {2021},
    issn = {1816-9155},
    doi = {aj.2021.34.40},
    url = {https://makhillpublications.co/view-article.php?issn=1816-9155&doi=aj.2021.34.40},
    author = {K.M.,Sanjar,Yatendra,Anil,K.M. and},
    keywords = {Cimetidine,microspheres,mucoadhesion,entrapment efficiency,bioavailability,in-vitro,gastrointestinal residence time},
    abstract = {Cimetidine is histamine (H<sub>2</sub> blocker). It is used
in the treatment of ulcer, acid-peptic disease and
heartburn. It is also known as an H<sub>2</sub>-receptor antagonist
who is responsible for inhibiting acid development in the
stomach. The Aim and objective of this work was to build
up a gastro retentive drug delivery system. The cimetidine
used as a model drug for making mucoadhesive dosage
form. This formulation can be achieved by using ionic
gelation method. The model drug used in this work plan
is categorized in the treatment of antiulcer. The
extended-release mucoadhesive microspheres of model
drug provide constant plasma concentration with a less
frequent administration and also reduce the side effects to
some extent. They provide good administration and
enhance patient compliance. The present study aims to
develop mucoadhesive microspheres of model drug using
Sodium alginate and Carbopol 934 used as an excellent
mucoadhesive agent which can adhere on the
gastrointestinal membrane for sustained drug delivery in
the stomach. The calcium chloride was also used for
making solvent system and to evaluate the model drug
mucoadhesive microspheres <i>in-vitro</i> for their drug release
pattern FTIR, SEM and DSC curve. The mucoadhesive
microspheres were prepared by ionic gelation method by
using polymers like carbopol 934 used as mucoadhesive
polymer and sodium alginate as rate controlling polymer.
Preformulation study shows no interaction between drug
and excipients. The prepared mucoadhesive microspheres
of cimetidine shows particle size of between
167.14-218.23 &#956;m. Entrapment efficiency of
formulations was found to be 70.06-87.67%. <i>In-vitro</i>
drug release after 7 h of F6 formulation show good
release was 85.60%. The surface morphology using
SEM of prepared microspheres reveals very smooth
surface with spherical shape. All prepared
formulations exhibits good percentage yield and
drug release rate. As the amount of sodium
alginates and calcium chloride was increased it
reduces percentage drug release. The increased amount
of polymer was raised significantly the particle size of
microspheres. <i>In-vitro</i> drug release studies were used for
indicating that there was a controlled and prolong release
of drug in the stomach and intestine. So, we can say the
formulation F6 was better candidate of all the developed
formulations.}
    }