@article{MAKHILLIJTM202015420012,
    title = {The Antioxidant Activity of Lycopene and β-Carotene of Tomato Fruit (Licopersicum
Pyriform) as Anti-Aging in Rats},
    journal = {International Journal of Tropical Medicine},
    volume = {15},
    number = {4},
    pages = {91-96},
    year = {2020},
    issn = {1816-3319},
    doi = {ijtmed.2020.91.96},
    url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2020.91.96},
    author = {Poncojari},
    keywords = {MDA,Photo aging,AP-1 expression,MMP-1 activity,collagen,design},
    abstract = {Photo aging is caused by a lack of collagen and
skin elastin fibers due to external factors such as solar UV
which may give negative effects on skin, for examples,
wrinkled, pigmentation spotted, low elasticity and hard
textures. The process of such an early aging may be
blocked or prevented by avoiding factors that may
accelerate it. However, so far no explanation has
suggested that the effect of lycopene or β-carotene may
give effects on ROS activity, AP-1 expression, MMP-1
activity and collagen in rats’ skin radiated by UV-B with
a dosage of 150 mJ cm<sup>&#150;2</sup>. The objective of this study was
to investigate the effect &#946;-caroten and lycopene on the
prevention of collagen damage due to the irradiation of
UV-B light. This current research used 24 rats divided
into 4 groups consisting of 6 rats each. The control group
was not irradiated by UV-B or not given tomato juice (P<sub>0</sub>).
The experimental group was given the following
treatments: exposure to UV-B light of 150 mJ cm<sup>&#150;2</sup> (P<sub>1</sub>),
exposure to UV-B light of 150 mJ cm<sup>&#150;2</sup> +&#946;-caroten (P<sub>2</sub>)
and exposure to UV-B irradiation with the dosage of
150 mJ cm<sup>&#150;2</sup>+lycopene (P<sub>3</sub>). Treatments were given to
each group for 6 weeks. An experimental design using a
cluster random with 4 treatments and 6 repetitions was
employed. AP-1 and MMP-activity were measured by
immunohistochemistry and the MDA content was
measured by means of NWLSS MDA Assay technique.
The data were analyzed using a variance analysis and then
followed by LSD test. It can be concluded that the
application of lycopen and &#946;-carotene may prevent the
aging by preventing the increase in MDA levels (as an
indicator of ROS activity) and the expression of AP-1,
also by a decrease in MMP-1 activity in the irradiated
skin by UV-B rays of 150 mJ cm<sup>&#150;2</sup>. However, it also
found that the application &#946;-carotene has shown no
significant difference compared to the application of
lycopene.}
    }