@article{MAKHILLIJTM201914119980, title = {Predictive Value of Self-reported History of Varicella in Colombo District, Sri Lanka}, journal = {International Journal of Tropical Medicine}, volume = {14}, number = {1}, pages = {5-10}, year = {2019}, issn = {1816-3319}, doi = {ijtmed.2019.5.10}, url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2019.5.10}, author = {Hathshya M.,Ananda,Neelika G. Malavige and}, keywords = {Colombo,predictive value,self-reported,Sero-prevalence,varicella,serological testing}, abstract = {To determine whether self-reported history of previous varicella infection is an accurate predictor of immunity to varicella. A population-based cross-sectional study of 1258 participants was conducted in Colombo District, Sri Lanka. Using interviewer-administered questionnaire, information on sociodemographic characteristics and previous history of varicella infection were obtained. A commercial enzyme-linked immunosobent assay kit was used to detect varicella zoster virus antibody IgG from serum samples. Self-reported varicella infection by the overall study group and by subgroups of adolescents, adults and women of childbearing age had a high positive predictive value (overall group, 92%; subgroups, 91-95%) for immunity to VZV. Whereas, a negative history of varicella infection was not an accurate predictor of nonimmune status, the negative predictive values were low for the overall group (76%) and subgroups (64-84%). For persons who are not at high risk of varicella infection, a positive history of varicella may be used to indicate positive immune status in lieu of serological testing. For those at high risk for varicella infection and a negative history of varicella infection, serological testing is required to determine immune status. For all those determined to the non-immune by serological testing, varicella vaccine should be offered.} }