Urinary tract infection (UTI) is a prevalent health issue in community and healthcare settings. The emergence of ESBL-producing and carbapenem-resistant Enterobacteriaceae limits treatment options, leading to multidrug resistance. This study investigated risk factors for multidrug resistance in Enterobacteriaceae isolated from UTI cases at a Gujarat tertiary care center, aiming to enhance understanding and develop effective treatment strategies. This retrospective observational study was conducted in a tertiary-care hospital, where urine samples from various departments, including the outpatient department (OPD), were analyzed. The isolates belonging to the Enterobacteriaceae group were identified using a range of biochemical methods. Subsequently, the ESBL and Carbapenemase producing organisms underwent antibiotic susceptibility testing following the guidelines provided by the Clinical and Laboratory Standards Institute (CLSI). In a Central Indian tertiary care hospital, 294 Enterobacteriaceae organisms were isolated from processed urine samples. Higher prevalence was observed among individuals aged 46-65 years and 16-30 years. Females had a higher incidence of UTIs caused by ESBL and Carbapenemase producers. Multidrug-resistant Enterobacteriaceae were more prevalent among indoor patients, particularly in the Surgery department. Common predisposing factors included catheterization, diabetes mellitus and obstructive uropathy. Among indoor patients, particularly those in the Surgery department, the prevalence of multidrug-resistant Enterobacteriaceae was notably higher. The most common risk factor associated with the presence of ESBL and carbapenemase producing organisms was catheterization.
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