@article{MAKHILLRJMS202317829340,
    title = {Efficacy of Metaxalone vs. Chlorzoxazone in Treating Musculoskeletal Pain: A Comparative Study},
    journal = {Research Journal of Medical Sciences},
    volume = {17},
    number = {8},
    pages = {20-24},
    year = {2023},
    issn = {1815-9346},
    doi = {10.59218\makrjms.2023.8.20.24},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9346&doi=10.59218\makrjms.2023.8.20.24},
    author = {Jarpala,P. and},
    keywords = {Musculoskeletal pain, metaxalone, chlorzoxazone, efficacy, safety profile, muscle relaxants, pharmacological intervention},
    abstract = {<p style="text-align:justify">Musculoskeletal pain, prevalent globally, often requires effective pharmacological intervention. This study compares Metaxalone and Chlorzoxazone, two commonly prescribed muscle relaxants, to ascertain their efficacy and safety profiles. This study aimed to compare the efficacy and safety of Metaxalone and Chlorzoxazone in patients suffering from musculoskeletal pain. Pain intensity levels were evaluated before and after the treatment period. The ability of the medications to improve daily functional activities was also assessed. Side effect profiles of both medications were monitored and reported. Pain intensity: Initial assessments showed patients in the Metaxalone group had an average pain score of 8.5, which decreased to 1.7 post-treatment, reflecting a mean reduction of 6.8 points. In contrast, the Chlorzoxazone group started with an average pain score of 8.4, decreasing to 2.5 post-treatment, with a mean reduction of 5.9 points. The additional 0.9 point reduction in the Metaxalone group was statistically significant (p = 0.043). Functional impairment: 92% of patients in the Metaxalone group (46/50) reported significant improvements in daily activities post-treatment. In comparison, 78% of patients in the Chlorzoxazone group (39/50) experienced improved daily functions. Side effects: Only 10% of patients (5/50) treated with Metaxalone reported mild side effects, while 18% (9/50) of those treated with Chlorzoxazone experienced mild adverse effects. While both Metaxalone and Chlorzoxazone are effective in alleviating musculoskeletal pain, Metaxalone exhibited marginally superior efficacy and a slightly better side effect profile. As such, Metaxalone may be considered a preferable option for patients seeking both pain relief and enhanced quality of daily living with fewer side effects.</p>
}
    }