@article{MAKHILLRJBS20094110821,
    title = {Anticariogenic Effect of Amorphous Calcium Phosphate Stabilized by Casein Phosphopeptid: A Review Article},
    journal = {Research Journal of Biological Sciences},
    volume = {4},
    number = {1},
    pages = {132-136},
    year = {2009},
    issn = {1815-8846},
    doi = {rjbsci.2009.132.136},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2009.132.136},
    author = {M. Moezizadeh and},
    keywords = {Milk,CPP,ACP,anticariogenic,enamel remineralization},
    abstract = {The anticariogenic potential of casein phosphopeptid-amorphous calcium phosphate nanocomplexes (CPP-ACP) has been demonstrated using laboratory, animal and human <I>in situ</I> caries model. The CPP-ACP has also been shown to remineralize enamel subsurface lesions <I>in vitro</I> and <I>in situ</I> when delivered in sugar-free gum. The proposed anticariogenic mechanism for CPP-ACP is the localization of ACP at the tooth surface which buffers the free calcium and phosphate ion activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel reducing demineralization and enhancing remineralization. The CPP-ACP therefore has exciting potential for use in oral care products and foods to help prevent dental caries and repair early stages of diseases, a development which will add significantly to dentists armoury of tools in preventive dentistry. This review article presents a brief on mechanism of action and role of CPP-ACP in caries prevention, remineralization of enamel lesions by CPP-ACP and use of CPP-ACP in different dental products like glass ionomer cement, tooth paste, mouth wash, tooth mousse and etc.}
    }