@article{MAKHILLRJBS20061110311,
    title = {Effect of Vitamin C on Cyproterone Acetate Induced Genotoxic Damage in Mice},
    journal = {Research Journal of Biological Sciences},
    volume = {1},
    number = {1},
    pages = {69-73},
    year = {2006},
    issn = {1815-8846},
    doi = {rjbsci.2006.69.73},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2006.69.73},
    author = {Yasir Hasan Siddique,Gulshan Ara,Tanveer Beg and},
    keywords = {Cyproterone acetate,vitamin c,chromosomal aberrations,sister chromatid exchanges,mice bone marrow cells},
    abstract = {The genotoxicity study of cyproterone acetate was carried out in mouse bone marrow cells using Sister Chromatid Exchanges (SCEs) and Chromosomal Aberrations (CAs) as a parameter. The effect of cyproterone acetate was studied at 6.25, 12.50 and 25.00 mg kg<SUP>-1</SUP> of body weight and was found to be genotoxic at 12.50 and 25.00 mg kg<SUP>-1</SUP> of body weight. Further the effect of vitamin C on 25.00 mg kg<SUP>-1</SUP> of body weight of cyproterone acetate was also studied. Three doses of vitamin C i.e. 20, 40 and 60 mg kg<SUP>-1</SUP> of body weight were given along with 25.00 mg kg<SUP>-1</SUP> of body weight of cyproterone acetate. Treatments along with vitamin C results in a significant decrease in CAs and SCEs suggesting an antigenotoxic role of vitamin C against cyproterone acetate induced genotoxic damage in mice bone marrow cells.}
    }