@article{MAKHILLIJMMAS2010638590, title = {Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena}, journal = {International Journal of Molecular Medicine and Advance Sciences}, volume = {6}, number = {3}, pages = {34-37}, year = {2010}, issn = {1813-176x}, doi = {ijmmas.2010.34.37}, url = {https://makhillpublications.co/view-article.php?issn=1813-176x&doi=ijmmas.2010.34.37}, author = {Anatoly L.,Vladimir P.,Alexey P. and}, keywords = {Hyper activation of the ATP synthesis,magnetic isotope effects,mitochondria function control,phenomenon,Zn+2 ion,nuclei}, abstract = {The rate of enzymatic ATP synthesis is shown to depend on the zinc isotopes. The ATP producing activities of creatine kinase and pyruvate kinase in which Zn2+ ions have magnetic nuclei 67Zn are found to be 2-6 times higher than that of enzymes in which Zn2+ ions have nonmagnetic nuclei 64Zn. The isolated rat heart muscle mitochondria exhibit a similar effect. An expression of this magnetic isotope effect in enzymatic ATP synthesis processed in the presence of Zn2+ ions is in a favor to the ion-radical mechanism of ATP production occurred within a high zinc concentration range. Both fundamental aspect and a possible pharmacological significance of the phenomenon described are under discussion.} }