@article{MAKHILLIJMMAS2005128484,
    title = {Loss of Synaptically Determined Viability of Neurons in Alzheimer Brain Atrophy},
    journal = {International Journal of Molecular Medicine and Advance Sciences},
    volume = {1},
    number = {2},
    pages = {143-148},
    year = {2005},
    issn = {1813-176x},
    doi = {ijmmas.2005.143.148},
    url = {https://makhillpublications.co/view-article.php?issn=1813-176x&doi=ijmmas.2005.143.148},
    author = {M. Lawrence. Agius},
    keywords = {Synaptically determind,brain athrophy,neuron,alzheimer},
    abstract = {Multiple exogenously derived systems of promotion and of induced progression would perhaps actually participate within contextual frameworks of self-promotion as age-related dementia. Indeed, impaired synaptic connectivity and impaired synaptic integrity might assume pathogenic roles leading to aspects of both induced and self-promotion towards pathways of evolving brain atrophy. Even beyond simple schemes of induced effect or of self-progression, however, synaptic transmission or non-transmission might help characterize the Alzheimer process as systems of disturbance arising from micro-circulatory ischemia to lack of neurotrophic effect to systems of nonviability of neurons and of neuronal non-responsiveness. In simple terms, the specific associations of the Alzheimer process with aging would appear a specific characterization of synaptic pathobiology central to basic dynamics of dementia both as an organic atrophic state and also as persistently active pathways of progression once initiated.}
    }