@article{MAKHILLJAVA201514134518, title = {Augmentation Effects of Novel Naringenin Analogues and Ciprofloxacin as Inhibitors for Nora Efflux Pump (EPIs) and Pyruvate Kinase (PK) Against MRSA}, journal = {Journal of Animal and Veterinary Advances}, volume = {14}, number = {13}, pages = {386-392}, year = {2015}, issn = {1680-5593}, doi = {javaa.2015.386.392}, url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2015.386.392}, author = {N.H.,Mohamed I. and}, keywords = {Naringenin analogues,pyruvate kinase,NorA efflux pump,MRSA}, abstract = {New naringenin derivatives bearing halogen moiety (1-6) were designed and synthesized. The structure of the newly synthesized compounds was elucidated by elemental analyses and spectral data. The in-vitro antimicrobial activity of the obtained compounds has been evaluated. All new analogues tested show inhibitory activity against microorganisms under investigation, the most potent compounds are 1-4. The rest of compounds show nearly same antimicrobial activity as ciprofloxacin reference drug used in this study. The new analogues showed also augmentation effect when used together with ciprofloxacin.} }