@article{MAKHILLJAVA201211163666,
    title = {Dietary L-Arginine Supplementation Improves the Immune Responses in Mouse Model Infected Porcine Circovirus Types 2},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {16},
    pages = {2980-2985},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.2980.2985},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.2980.2985},
    author = {Wenkai,Wei,Yinghui,Miaomiao,Dingding,Gang,Xinglong,Tiejun and},
    keywords = {L-arginine,porcine circovirus types 2,C-reactive protein,mouse model,dietary},
    abstract = {This study was conducted to test the hypotheses that dietary L-arginine supplementation may enhance the immune responses and resulting in the clearance against PCV2 in experimentally infected mice. The measured variables include: the PCV2 virus load in liver, spleen, heart, lung, kidney, ovary and serum on 3rd, 5th, 7th, 9th and 11th day post infection (dpi); serum Interleukin-2 (IL-2), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Interferon alpha (IFN-α), Interferon gamma (IFN-γ) and C-Reactive Protein (CRP) levels on 3rd, 5th, 7th, 9th and 11th dpi; serum Total Superoxide Dismutase (T-SOD) activity on 3rd, 5th, 7th, 9th and 11th dpi. Results showed that arginine supplementation could significantly increase the serum IL-2 levels on the 9th and 11th dpi; significantly increase the serum IFN-α and CRP levels on the 11th dpi; significantly increase the serum IFN-r levels on the 7th dpi and significantly decrease the serum IL-6 levels on the 9th dpi. Meanwhile, the PCV2 virus genome was detected sporadically. Collectively, dietary L-arginine supplementation had beneficial effects on the cytokines profile in the PCV2 infected mouse and maybe could delay the PCV2 replication and/or clear the PCV2 in mouse model.}
    }