@article{MAKHILLJAVA20109222485,
    title = {Changes in Glycolipid Metabolism During A High-Sucrose Feeding in Spontaneously Diabetic Torii (SDT) Rats, A Genetic Model of Nonobese Type 2 Diabetes},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {9},
    number = {22},
    pages = {2883-2889},
    year = {2010},
    issn = {1680-5593},
    doi = {javaa.2010.2883.2889},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2010.2883.2889},
    author = {Takeshi,Katsuhiro and},
    keywords = {Diabetes,high-sucrose diet,rat,abnormality,fatty liver,serum},
    abstract = {A high-sucrose diet induces insulin resistance and dyslipidemia in normal rats. The purpose of the present study was to investigate the effects of a high-sucrose diet on glycolipid metabolism in Spontaneously Diabetic Torii (SDT) rats, a genetic model of nonobese type 2 diabetes. Male SDT rats were fed with a high-sucrose (68% of energy) diet from 8-24 weeks of age. SDT rats fed a high-sucrose diet showed hypercholesterolemia, hyperinsulinemia and hyperleptinemia but the body weight and the serum triglyceride level were not increased. Unexpectedly in SDT rats fed a high-sucrose diet, we observed a suppress of the incidence of diabetes mellitus. In computed tomography analysis, SDT rats fed a high-sucrose diet showed an increase of visceral or subcutaneous fat tissue weight. In pathological analyses, slight or mild fatty liver was observed by high-sucrose feeding. A high-sucrose diet in SDT rats induced dyslipidemia, insulin resistance and fat storage but not development of diabetes. High sucrose-fed diabetic rats are considered to be useful for further elucidation of complex mechanisms in glycolipid metabolic abnormality.}
    }