@article{MAKHILLJAVA2010911958,
    title = {Effects of Extract of Green Tea and Ginseng on Pancreatic Beta Cells and Levels of Serum Glucose, Insulin, Cholesterol and Triglycerides in Rats with Experimentally Streptozotocin-Induced Diabetes: A Histochemical and Immunohistochemical Study},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {9},
    number = {1},
    pages = {102-107},
    year = {2010},
    issn = {1680-5593},
    doi = {javaa.2010.102.107},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2010.102.107},
    author = {Ibrahim,Mecit,Turan and},
    keywords = {hypoglycaemia,pancreatic b-cell,diabetes mellitus,ginseng,Green tea,streptozotocin},
    abstract = {This study investigated the effects of oral administration of extract of green tea (<I>Camellia sinensis</I>) and ginseng (American ginseng<I>-Panax quinquefolium L</I>.), given alone or together, on pancreatic &#946;-cells, blood glucose, insulin, cholesterol and triglyceride levels in rats with experimental diabetes induced by a single injection of Streptozotocin (STZ) (60 mg kg<SUP>-1</SUP>, i.p.). Fifty adult Wistar Albino rats were used, 10 in each of these five treatment groups: Group A: healthy controls, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus green tea extract (100 mg/kg/daily), Group D: STZ-induced diabetes plus ginseng root (400 mg/kg/daily) and Group E: STZ-induced diabetes plus ginseng root + green tea extracts as before. At the end of the 6 weeks experiment, blood samples were analysed for blood glucose, insulin, cholesterol and triglyceride levels and samples of pancreatic tissue were examined histochemically and immunohistochemically for endocrine islets and &#946;-cells. Overall, body weight decreased in groups B and C, serum insulin concentrations decreased slightly in groups C-E and total triglyceride levels of blood decreased significantly (p&lt;0.05) in groups B and C compared with control, D and E groups. Histopathological examination showed that degenerative changes in pancreatic &#946;-cells in STZ-treated rats were minimised to near normal morphology by administration of ginseng (Group D) and ginseng+green tea (Group E) and there was increased intensity of immunohistochemical staining for insulin in these groups. Degeneration of islets of Langerhans &#946;-cells and weak insulin staining was observed for green tea alone (Group C). These findings demonstrate that ginseng or combined ginseng + green tea decreases blood glucose levels in diabetic rats and increases preservation of &#946;-cells, perhaps by lowering oxidative stress.}
    }