@article{MAKHILLJAVA20098121920, title = {Comparison of Central Effects of L-Ornithine Metabolites on the Stress Responses of Neonatal Chicks}, journal = {Journal of Animal and Veterinary Advances}, volume = {8}, number = {12}, pages = {2580-2584}, year = {2009}, issn = {1680-5593}, doi = {javaa.2009.2580.2584}, url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2009.2580.2584}, author = {I.,K.,S.,M.,Y.,K.,D.M. and}, keywords = {L-ornithine,D-ornithine,L-citrulline,intracerebroventricular injection,social separation stress,neonatal chick}, abstract = {Recently, we observed that central administration of L-arginine attenuated the stress responses of neonatal chicks by inducing a sedative and hypnotic effect. In addition, L-ornithine, which is produced from L-arginine in the brain, appeared to interact with L-arginine during a stress response. Several putative metabolites from L-ornithine, including L-citrulline and D-ornithine, were therefore investigated in the present study. The effects of intracerebroventricular injection of L-ornithine, L-citrulline and D-ornithine were compared in chicks under an isolation-induced stress. L-ornithine greatly attenuated the stress response and induced sedative and hypnotic effects. D-ornithine weakly attenuated the stress responses, while L-citrulline had no effect.} }